Vitality Rune

Vitality Rune may refer to:
 * Vitality Rune (Spell), a Rune Spell in SaGa Frontier 1.
 * Vitality Rune (Item), one of the Rune Stones required for the Gift of Rune Magic.
 * Vitality Rune (Quest), the actual quest taken to acquire the Vitality Rune (Item).